Molecular Characterization and Engineering for the Development of a Transmission-Blocking Malaria Vaccine

BR McLeod - 2023 - search.proquest.com
… , Plasmodium falciparum, while in the mosquito vector, so the … of antibody recognition of
leading transmission-blocking … New adenovirus-based vaccine vectors targeting Pfs25 elicit

[HTML][HTML] Sterile protection and transmission blockade by a multistage anti-malarial vaccine in the pre-clinical study

M Iyori, AM Blagborough, T Mizuno, Y Abe… - Frontiers in …, 2022 - frontiersin.org
… a multistage malaria vaccine (targeting both PfCSP and the … Pf(s25-CSP), an adenovirus-based
vaccine that has previously … -lasting antibody induction with a high level of anti-Pfs25 IgG …

[HTML][HTML] Poor CD4+ T Cell Immunogenicity Limits Humoral Immunity to Pfalciparum Transmission-Blocking Candidate Pfs25 in Humans

M Zaric, A Marini, CM Nielsen, G Gupta… - Frontiers in …, 2021 - frontiersin.org
… this study, the transmission reducing activity of the antibodies … responses over human elicited
to the same vaccine, we … dynamics of humoral immunity targeting the Pfs25-IMX313 domain …

[HTML][HTML] Recent advances in the development of adenovirus-vectored vaccines for parasitic infections

C Koger-Pease, DJ Perera, M Ndao - Pharmaceuticals, 2023 - mdpi.com
… in AdV-vectored vaccines targeting five major human parasitic … There is a notable lack
of vaccines that effectively elicit … using HAdV-5 expressing Pfs25 (a sexual stage protein) [93]. …

[HTML][HTML] A Pvs25 mRNA vaccine induces complete and durable transmission-blocking immunity to Plasmodium vivax

N Kunkeaw, W Nguitragool, E Takashima… - npj Vaccines, 2023 - nature.com
… Taken together, we report on mRNA vaccines targeting P. … construct Pvs25F elicited the
strongest antibody responses at … the antibody responses reported in Pfs25 vaccine studies 42 . …

[HTML][HTML] Safety and immunogenicity of ChAd63/MVA Pfs25-IMX313 in a phase I first-in-human trial

H De Graaf, RO Payne, I Taylor, K Miura… - Frontiers in …, 2021 - frontiersin.org
… The Plasmodium falciparum Pfs25 protein (Pfs25) is a leading candidate antigen for a …
Pfs25 was identified as the target of highly effective transmission-blocking monoclonal antibodies

[HTML][HTML] Signatures of selection and drivers for novel mutation on transmission-blocking vaccine candidate Pfs25 gene in western Kenya

KO Ochwedo, SA Onyango, CJ Omondi, PW Orondo… - Plos one, 2022 - journals.plos.org
… as Plasmodium falciparum surface protein 25 (Pfs25 gene) … were used to amplify the target
Pfs25 gene. Amplification of … interaction between host antibodies elicited by Pfs25 TBV and …

Malaria vaccines

M Quagliata, AM Papini, P Rovero - Expert Opinion on Therapeutic …, 2023 - Taylor & Francis
… under natural conditions: Plasmodium falciparum (P. … vaccines are designed to prevent
disease through targeting of … and were therefore exploited to elicit immune response. For example…

[HTML][HTML] Vaccination against the Epstein–Barr virus

J Rühl, CS Leung, C Münz - Cellular and Molecular Life Sciences, 2020 - Springer
vaccines, but also envelope proteins are explored as targets … carcinoma and Plasmodium
falciparum antigen displaying … immunogenic vaccines elicited virus-neutralizing antibody

Recent advances in immunotherapies against infectious diseases

D Ramamurthy, T Nundalall, S Cingo… - Immunotherapy …, 2021 - academic.oup.com
… in clinical trials, including an adenovirus-based vaccine for … falciparum transmission-blocking
vaccine candidate Pfs25 [… vector to host transmission by targeting the sexual stage of P. …